Welcome to the Vogel Wise Research Pages

Our interests:
Drug Discovery, Protein Dynamics, Multidrug Resistances in Cancer Chemotherapy, Antibiotic Resistances and Nano-Molecular Motors

Our Approaches:
Biochemical, Biophysical, Cell Biological and Computational

Our philosophy:
Interdisciplinary synergies and energetic, dedicated researchers accelerate results.

"Don't only practice your art, but force your way into its secrets, for it and knowledge can raise men to the devine."
- Ludwig von Beethoven

P-gp pumping daunorubicin Pia and John (picture) P-gp with inhibitors bound

John G. Wise, Ph.D.

Ph.D. University of Rochester

Office: 234 Dedman Life Sciences
Tel: 214.768.3426
Fax: 214.768.3955
Email: jwise@smu.edu

Click here for John's publications.

Dr. rer. nat. habil. Pia D. Vogel

Ph.D. Universitaet Kaiserslautern

Office: 233 Dedman Life Sciences
Tel: 214.768.1790
Fax: 214.768.3955
Email: pvogel@smu.edu

Click here for Pia's publications.
Lab Address:
220 and 221 Dedman Life Sciences
Southern Methodist University
6501 Airline Ct.
Dallas, TX 75275-0376

Lab Phones: 214-768-2764 or 214-768-1785
Shipping Address:
Department of Biological Sciences
Southern Methodist University
6501 Airline Ct.
Dallas, TX 75205-0376

Recent press releases:


Supercomputers enabling-cancer-drug-discovery

Dynamic models of drug resistance proteins

Video popularizations of our work:
compounding hope video link
Video link to innner workings computer disoveries of MDR inhibitors

Multiple Drug Resistance Proteins
Journal cover page for Biochemistry - Oct- Dec 2015

Drug discovery and optimization for multidrug drug resistant cancers

Structural and Drug Transport Mechanism studies

Small molecule drug docking

Virtual screening technologies for new inhibitors

Rotary Motors from Biology and ATP Synthase Research

Enzymatic mechanism studies

Mechanisms of multisite cooperative catalysis

Mechanisms of ligand binding in complex multisubunit systems

Membrane protein complex ion-pumping mechanisms in coupled membrane systems

Our People

Information on our dedicated researchers

John Wise at Biology at SMU

John's Science Website

Pia Vogel at Biology at SMU

Pia's Website at the Department of Biological Sciences at SMU website

Biology at SMU

The Department of Biological Sciences at SMU website

SMU Center for Drug Discovery, Design and Delivery

  CD4 logo

Big Problems with Intelligent Design and Discovery Institute

The Discovery Institute visited SMU on September 23, 2010. This was my response the next day.

Many thanks to the following for support:

The National Institutes of Health
The Communities Foundation of Texas
The SMU University Research Council
The SMU Dedman College Dean's Research Council
The SMU Hamilton Undergraduate Research Scholar Program
The SMU Engaged Learning Program

We would also like to give special thanks to Ms. Suzy Ruff of Dallas, Texas for her enthusiastic and generous support of our work and to Ms. Lynn McBee and New England Biolabs for their generous help with reagents.